Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)
Camus, J.P.; Crouzet, J.; Prier, A.; Leca, A.P.
Revue du Rhumatisme et des Maladies Osteo-Articulaires 44(12): 721-724
1977
ISSN/ISBN: 0035-2659 PMID: 609877 Document Number: 117604
A comparison of two series of patients with rhe,matic polyarthritis, the one (n = 140) treated with dosage equal to or higher than 900 mg, the other (n = 60) with dosage between 600 and 750 mg, did not reveal significant difference in clinical and biological efficacy. The number of side-effects was not significantly reduced by lower dosage, except for digestive tract disorders. A reduction of dosage does, therefore, not permit less strict supervision and monitoring for side-effects of treatment.