Dapiprazol antagonizes tropicamide- and phenylephrine-induced mydriasis in the elderly
Warlich, M.; Weik, R.; Höh, H.; Ruprecht, K.W.
Der Ophthalmologe Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 92(2): 179-181
1995
ISSN/ISBN: 0941-293X PMID: 7780277 Document Number: 443678
Dapiprazole eye drops were applied 1 h after topical tropicamide or phenylephrine instillation in 30 elderly subjects. Pupil diameter normalized much earlier than in controls receiving placebo. Dapiprazole constricted the tropicamide-dilated pupil by 1 mm after 1 h and normalized the pupil diameter of the phenylephrine-dilated pupil within 1 h, whereas the pupils of the patients receiving placebo remained dilated. Intraocular pressure did not change; no major side effects were seen.