Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens
Arruzazabala, M.L.; Pérez, Y.; Ravelo, Y.; Molina, V.; Carbajal, D.; Mas, R.; Rodríguez, E.
Indian Journal of Experimental Biology 49(9): 684-688
2011
ISSN/ISBN: 0019-5189 PMID: 21941942 Document Number: 650228
D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits alpha1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 microg/mL), oleic (100 microg/mL), lauric (50 microg/mL) or myristic (25 microg/mL) acids and their combined effects on phenylephrine (PHE: 10(-7)-10(-4) mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions.