Available animal models of osteopenia--small and large
Miller, S.C.; Bowman, B.M.; Jee, W.S.
Bone 17(4 Suppl): 117s-123s
1995
ISSN/ISBN: 8756-3282 PMID: 8579907 Document Number: 442845
Animal models of osteopenia are reviewed. Endocrine excess or deficiency conditions include ovariectomy, orchidectomy, glucocorticoid excess and other endocrine states. Seasonal and reproductive cycles are usually transient and include pregnancy and lactation, egg-laying, antler formation and hibernation. Dietary conditions include calcium deficiencies, phosphate excess and vitamin C and D deficiencies. Mechanical usage effects include skeletal underloading models. Aging is also associated with osteopenia in many species.