Animal models of arthritis. What have we learned?
van den Berg, W.B.
Journal of Rheumatology. Supplement 72: 7-9
2005
ISSN/ISBN: 0380-0903 PMID: 15660455 Document Number: 586625
Animal models of arthritis can be used to understand elements of the arthritic process in patients. Recent therapeutic approaches in patients with rheumatoid arthritis (RA) with biologics are based on initial findings in murine models of experimental arthritis, although final proof of concept must come from clinical studies. Animal models are powerful tools for studying pathologic changes in articular cartilage and bone in teat detail, and can to used to evaluate mechanisms of erosive processes. Although in general more inflammation drives more destruction. the uncoupling of inflammation and erosion can be seen as well. and different mediators are involved in these processes.