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Susceptibility to rubella infection in females at high risk. Immune protection associated to population density

Yamamoto, L.; Mejia, E.; López, R.M.; Gallardo, E.; Gómez, B.

Tropical and Geographical Medicine 47(6): 235-238

1995

ISSN/ISBN: 0041-3232
PMID: 8650731
Document Number: 442582
Susceptibility to rubella in 428 Mexican females of childbearing age from four sanitary areas confined to a Mexican State (Queretaro) was determined. Members of the group were residents of urban and rural communities and selected by random sampling. Anti-viral antibodies were determined by inhibition of haemagglutination. Concentration was expressed as International Units of IgG anti-rubella haemagglutinin (IU/ml). Antibody concentrations lower than 15.6 (IU/ml) were regarded as non-protective. The percentage of women immune-protected to rubella in the areas varied from 28.8 to 75.6 with an average of 61.9. The difference in percentages of immune-protected females within the areas was statistically significant (chi 2 = 48.26 and p < 0.001). Immune protection was associated to population density, with less protection in less populated areas. Our results differ from the reported values of a serosurvey performed in the same state one year before: immune protection 61.9% versus 79.96%, respectively.

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