Nonsteroidal anti-inflammatory drug-induced colonic strictures: two cases and literature review
Gargot, D.; Chaussade, S.; d'Alteroche, L.; Desbazeille, F.; Grandjouan, S.; Louvel, A.; Douvin, J.; Causse, X.; Festin, D.; Chapuis, Y.
American Journal of Gastroenterology 90(11): 2035-2038
1995
ISSN/ISBN: 0002-9270 PMID: 7485018 Document Number: 441715
We report two patients with large bowel submucosal diaphragm disease associated with nonsteroidal anti-inflammatory drugs (slow release form of diclofenac and phenylbutazone) who were admitted in 1990 and 1991 because of iron deficiency. At colonoscopy, the lumen of the ascending colon was divided into compartments by multiple thin circumferential mucosal membranes. Barium enema showed two short strictures in one patient. Right hemicolectomy was carried out on one patient. The other patient was simply advised to discontinue taking diclofenac and remains well. Such lesions are rare (10 cases have been reported) and resemble those previously described in the small bowel.