Nephrotic syndrome associated with nonsteroidal anti-inflammatory drug use in two children
Robinson, J.; Malleson, P.; Lirenman, D.; Carter, J.
Pediatrics 85(5): 844-847
1990
ISSN/ISBN: 0031-4005 PMID: 2184411 Document Number: 356133
Two children with nephrotic syndrome in association with nonsteroidal anti-inflammatory drug (NSAID) use are described, and the literature concerning this association is reviewed. NSAIDs are drugs with the potential for causing significant renal toxicity including the nephrotic syndrome, interstitial nephritis, and renal failure even in children without obvious preceding renal disease. Children prescribed such drugs should be regularly monitored with urinalyses and plasma creatinine estimations. The possibility of toxicity to over-the-counter use of NSAIDs should be remembered.