Nonsteroidal anti-inflammatory drug-induced diaphragm disease arising in a bypassed ileal segment
Monihan, J.M.; Hensley, S.D.; Sobin, L.H.
American Journal of Gastroenterology 89(4): 610-612
1994
ISSN/ISBN: 0002-9270 PMID: 8147367 Document Number: 423431
The formation of mucosal ileal diaphragms has been previously reported in patients receiving nonsteroidal anti-inflammatory drugs over extended periods of time. Whether this effect is the result of a local or systemic action by the medication has remained unknown. We report the first known instance of diaphragm disease arising in a segment of ileum that had been bypassed for many years and therefore was not exposed normally to luminal contact with the drug. This case supports at least a partial systemic mechanism in the production of the lesion.