Biology of blood progenitor cells used in transplantation
Pettengell, R.; Testa, N.G.
International Journal of Hematology 61(1): 1-15
1995
ISSN/ISBN: 0925-5710 PMID: 7718764 Document Number: 441579
Blood progenitor cells (BPC) are increasingly used in a variety of clinical settings. These include autologous and allogeneic transplantation after myeloablative therapy, and gene therapy. The optimal blood products for each of these applications have not been defined. The use of different cytotoxic drugs and cytokines, alone and in combination, results in the mobilisation of different total numbers and relative proportions of primitive and committed BPC. Some cytotoxics and cytokines not only are poor at mobilising BPC, but also are myelotoxic. Here we review the biology of BPC mobilisation and its implications for their clinical use.
Document emailed within 1 workday
Related Documents
Champlin, R.E. 1996: Peripheral blood progenitor cells: a replacement for marrow transplantation? Seminars in Oncology 23(2 Suppl 4: 15-21Schmitz, N.; Bacigalupo, A.; Labopin, M.; Majolino, I.; Laporte, J.P.; Brinch, L.; Cook, G.; Lambertenghi-Deliliers, G.; Lange, A.; Rozman, C.; Garcia-Conde, J.; Finke, J.; Domingo-Albos, A.; Gratwohl, A. 1996: Transplantation of allogeneic peripheral blood progenitor cells--the EBMT experience Bone Marrow Transplantation 17(Suppl 2): S40-S46
Cinek, P.; Filip, S.; Vanasek, J.; Mericka, P.; Blaha, M.; Zouhar, M. 2007: Intensive cyclic chemotherapy and transplantation of autologous peripheral blood progenitor cells (PBPC) or whole blood in high-risk breast cancer - follow up at 10 years Experimental Oncology 29(2): 144-151
Vítek, A.; Sajdová, J.; Hrabánek, J.; Kobylka, P.; Korínková, P.; Gasová, Z.; Loudová, M.; Cukrová, V.; Dolezalová, L.; Marinov, J.; Sieglová, Z.; Hrubá, A. 1998: Transplantation of allogeneic peripheral blood progenitor cells--a single centre experience Bone Marrow Transplantation 22(Suppl 4): S73-S76
Dreger, P.; Glass, B.; Uharek, L.; Zeis, M.; Schmitz, N. 1997: Allogenic transplantation of mobilized peripheral blood progenitor cells: towards tailored cell therapy International Journal of Hematology 66(1): 1-11
Chaisiripoomkere, W.; Jootar, S.; Ungkanont, A.; Jaovisidha, A.; Onpun, S.; Khupulsup, K. 1999: Study of hematopoietic progenitor cells, hematological values and lymphocyte subsets in cord blood: application for cord blood transplantation Southeast Asian Journal of Tropical Medicine and Public Health 30(4): 781-785
Ghielmini, M.; Tobler, A. 1996: Mobilization and transplantation of autologous hematopoietic stem and progenitor cells from peripheral blood: principles and applications Schweizerische Medizinische Wochenschrift 126(9): 348-356
Finke, J.; Brugger, W.; Bertz, H.; Behringer, D.; Kunzmann, R.; Weber-Nordt, R.M.; Kanz, L.; Mertelsmann, R. 1996: Allogeneic transplantation of positively selected peripheral blood CD34+ progenitor cells from matched related donors Bone Marrow Transplantation 18(6): 1081-1086
Hołowiecki, J.; Wojnar, J.; Markiewicz, M.; Wacławik, A.; Jagoda, K.; Kamińska, H.; Kachel, L.; Wojciechowska, M.; Kata, D. 1995: Autologous peripheral blood stem and progenitor cells transplantation as a valid treatment approach in recurrent, refractory lymphoma Archivum Immunologiae et Therapiae Experimentalis 43(3-4): 191-194
Dreger, P.; Viehmann, K.; Steinmann, J.; Eckstein, V.; Müller-Ruchholtz, W.; Löffler, H.; Schmitz, N. 1995: G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: comparison of T cell depletion strategies using different CD34+ selection systems or CAMPATH-1 Experimental Hematology 23(2): 147-154
Grimaz, S.; Damiani, D.; Michieli, M.; Baccarani, M. 2000: Mobilization of peripheral blood progenitor cells with G-CSF alone in lymphoma patients: steady-state circulating progenitor cell count predicts the autograft yield Haematologica 85(1): 102-103
García Laraña, J.; Díaz Mediavilla, J.; Martínez, R.; Lahuerta, J.J.; Alegre, A.; Odriozola, J.; Sureda, A.; San Miguel, J.; De la Rubia, J.; Escudero, A.; Conde, E.; Bladé, J.; Cabrera, R.; Gastearena, J.; Besalduch, J.; Vidal, M.J.; Hernández, F.; Rifon, J.; Leon, A.; Mataix, R.; Parody, R.; Moraleda, J.M.; Solano, C.; de Pablos, J.M.; Sánchez, J.J. 1997: Maintenance treatment with interferon-alfa in multiple myeloma after autotransplantation of peripheral blood progenitor cells. Spanish Register of Transplantation in Myeloma Sangre 42(Suppl 1): 38-41
Jungerman, M.; Sedzimirska, M.; Lange, A.; Witt, M. 1998: Application of microsatellite markers for monitoring of reconstitution pattern in patients after bone marrow transplantation/peripheral blood progenitor cell transplantation Archivum Immunologiae et Therapiae Experimentalis 46(1): 39-43
Bolwell, B.J.; Fishleder, A.; Andresen, S.W.; Lichtin, A.E.; Koo, A.; Yanssens, T.; Burwell, R.; Baucco, P.; Green, R. 1993: G-CSF primed peripheral blood progenitor cells in autologous bone marrow transplantation: parameters affecting bone marrow engraftment Bone Marrow Transplantation 12(6): 609-614
Gray, T.F.; Shea, T.C. 1994: Current status of peripheral blood progenitor cell transplantation Seminars in Oncology 21(5 Suppl. 12): 93-101
Numata, M.; Koizumi, S.; Horita, S.; Ueno, Y.; Yamagami, M.; Taniguchi, N. 1985: Different Ia antigen characterization between granulocyte progenitor cells (CFC-G) and monocyte-macrophage progenitor cells (CFC-M) Experimental Hematology 13(8): 827-832
Hernández, M.D.; del Cañizo, M.C.; González, M.; Caballero, M.D.; López-Berges, M.C.; Vázquez, L.; Orfao, A.; Corral, M.; Nieto, M.J.; San Miguel, J.F. 1998: Immune reconstitution after autologous progenitor hemopoietic cell transplantation. a study comparing autologous bone marrow and autologous peripheral blood transplantation Medicina Clinica 110(20): 768-773
Szer, J.; Bardy, P.; Grigg, A.; Durrant, S.; Hutchins, C.; Herrmann, R.; Atkinson, K. 1996: Allogeneic peripheral blood progenitor cell transplantation--the Australian experience Bone Marrow Transplantation 17(Suppl 2): S51-S53
Balint, B.; Ivanović, Z.; Petakov, M.; Taseski, J.; Vojvodić, D.; Jovcić, G.; Bugarski, D.; Marjanović, S.; Malesević, M.; Stojanović, N. 1999: Evaluation of cryopreserved murine and human hematopoietic stem and progenitor cells designated for transplantation Vojnosanitetski Pregled 56(6): 577-585
Perrier, L.; Sebban, C.; Philip, I.; Standaert, B.; Morelle, M.; Latour, J.F.; Biron, P.; Philip, T. 2002: Necessary harmonization of health cost assessment. Autologous peripheral blood progenitor cell transplantation in France Revue d'Epidemiologie et de Sante Publique 50(4): 393-403