Detection of undegraded beta-lactoglobulins and evaluation of the molecular weight of peptides in hydrolysate cow's milk formulae
Chiancone, E.; Gattoni, M.; Giampietro, P.G.; Ragno, V.; Businco, L.
Journal of Investigational Allergology and Clinical Immunology 5(4): 228-231
1995
ISSN/ISBN: 1018-9068 PMID: 8705014 Document Number: 441538
The aim of this study was to investigate the presence of intact cow milk proteins and the molecular weights of peptides in several batches of 2 types of extensively-hydrolysed infant formulae and 2 partially-hydrolysed formulae. The results show the presence of a significant amount of intact beta -lactoglobulin in 1 of the partially-hydrolysed infant formula and of peptides with high molecular weights (>16 900 Da) in the 2 partially-hydrolysed formulae. It was concluded that partially-hydrolysed formulae contain a large proportion of peptides with high molecular weights; in addition, undegraded beta -lactoglobulin was detected in a partially-hydrolysed whey formula. These data strongly indicate that partially-hydrolysed formulae may be not only allergenic in an already sensitized individual, but also immunogenic in a predisposed baby.