Clinical experience with a low dose oral contraceptive containing norethisterone and ethinyl oestradiol
Morigi, E.M.; Pasquale, S.A.
Current Medical Research and Opinion 5(8): 655-662
1978
ISSN/ISBN: 0300-7995 PMID: 710178 DOI: 10.1185/03007997809110203Document Number: 439677
Clinical experience with a low dose oral contraceptive (OC) containing .5 mg norethisterone and .035 mg ethinyl estradiol is reported. 1168 sexually active women received the OC as a 21-day cyclic regimen from 1 to 53 cycles with an overall total of 16345 cycles. No pregnancies occurred when the OC was taken as directed. 3 women who conceived during the study missed 3, 2, and 1 prescribed tablets, respectively. The overall pregnancy rate was .22/100 woman years of use calculated as a Pearl index. Spotting and/or breakthrough bleeding was noted primarily in the early cycles. Patient dropout was 14.2% for menstrual disorders and irregularities, and 11.4% for other medically associated complaints or reactions. It is concluded that this OC has proved to be an effective and well-tolerated lower dose OC.