Protective effect of a beta-1,3-carboxymethylglucan in acute massive blood loss
Vereshchagin, E.I.; Korolenko, T.A.; Shandula, I.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1994(3): 33-35
1994
ISSN/ISBN: 0031-2991 PMID: 7824342 Document Number: 438861
Experiments were performed on CBA mice to study the effect of intravenous injections of beta-1,3-f-carboxymethylglucan (Bratislava, Slovakia) during acute massive blood loss (50% of the total blood volume). Two different fractions were used in doses of 25 mg/kg of body weight. The first fraction (semisoluble, its molecular weight being about 10-6) was shown to have a potent protective effect when it was injected 24 h before blood loss. On the contrary, the other fraction (water soluble, its molecular weight being less than 1.2 cntdot 10-6) showed no protective effect. Moreover, injection of this fraction 72 h before blood loss can lead to increases in deaths among the mice.