Regeneration of the gastric mucosa under conditions of massive blood loss
Potashov, L.V.; Berlin, L.B.; Klimashevskiĭ, V.F.; Sedov, V.M.
Arkhiv Anatomii Gistologii i Embriologii 70(2): 65-68
1976
ISSN/ISBN: 0004-1947 PMID: 1083232 Document Number: 100056
The autoradiographic method was used for a comparative study of regeneration of the gastric mucosa after wounding the rat with a preliminary loss of blood and without it. The H3-thymidin label index was determined in the portions of the mucosa of the wound edge and far from it. A histological analysis of healing the wounds failed to reveal any difference in terms of this process in rats with a loss of blood and without it. A momentary massive loss of blood did not influence the strain and intracellular regeneration processes in the healing wound of the stomach: the amount of cells synthesizing DNA at the edges of the gastrotonic wound proved to be the same in experiments both with a loss of blood and without it. The authors believe that it may serve as an indirect evidence of a somewhat exaggerated danger of surgery at the height of gastroduodenal bleeding.