Metabolic and endocrinological responses to the infusion of a new intraoperative fluid
Azuma, J.; Yamamoto, I.; Takaori, M.
Masui. Japanese Journal of Anesthesiology 43(8): 1148-1160
1994
ISSN/ISBN: 0021-4892 PMID: 7933495 Document Number: 437658
A new intraoperative fluid, which is characterized by containing 10 mEq cntdot l-1 of potassium, 140 mEq cntdot l-1 sodium and 1% glucose, was infused into 18 healthy volunteers either at rate of 5, 10 ml cntdot kg-1 cntdot h-1 (for 3 hours) or 15 ml cntdot kg-1 cntdot h-1 (for 2 hours). Responding to increase in the infusion rate and volume, blood glucose and insulin (IRI) levels increased slightly but remained in the normal range. On the other hand, lipid metabolism was depressed markedly. Although concentrations of both potassium and sodium in serum remained unchanged, sodium and water balance (intake vs. outflow) became absolutely positive. Potassium balance was maintained at zero. Blood renin activity decreased gradually after the infusion was commenced and remained at a lower level for 3 hours after stopping infusion. Blood aldosterone and antidiuretic hormone levels also decreased but more gradually than the decrease of blood renin activity. Noteworthy change was not observed in the variables relating to hepatic and renal functions.