Suppression of FcRIi by intravenously administerd IgG is dependent of preparation procedures of immunoglobulins
Greinacher, A.; Möckel, M.; Mueller-Eckhardt, C.
Beitrage Zur Infusionstherapie und Transfusionsmedizin 32: 211-213
1994
ISSN/ISBN: 1023-2028 PMID: 9480090 Document Number: 436903
The effect of different i.v. IgG preparations on FcRII-dependent platelet activation by antibodies from patients with heparin-associated thrombocytopenia (HAT) was investigated. Only one preparation (treated with pH 4 and traces of pepsin) sufficiently inhibited FcRII-dependent platelet activation (20 mg/ml). We conclude that administration of high-dose i.v. IgG is efficient for acute treatment of HAT, dependent on the manufacturing process.