Investigation of a novel preparation of testosterone decanoate in men: Pharmacokinetics and spermatogenic suppression with etonogestrel implants
Anderson, R.A.; Zhu, H.; Cheng, L.; Baird, D.T.
Contraception 66(5): 357-364
2002
ISSN/ISBN: 0010-7824 PMID: 12443967 DOI: 10.1016/s0010-7824(02)00390-6Document Number: 244251
We have investigated the pharmacokinetics and effects on the male reproductive axis of a novel preparation of testosterone decanoate (TD) with a progestogen implant. Twenty healthy Chinese men were administered TD (400 mg intramuscular 4 weekly) with two subcutaneous (SC) etonogestrel implants. Trough testosterone concentrations rose with repeated administration. Peak concentrations 1 week after the fourth injection were 31 +/- 2 nmol/liter. Both LH and FSH were rapidly suppressed and continued to fall during treatment. Spermatogenesis was also suppressed, to
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