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Suppressive effect of 1,2-dibromo-3-chloropropane on human spermatogenesis

Potashnik, G.; Ben-Aderet, N.; Israeli, R.; Yanai-Inbar, I.; Sober, I.

Fertility and Sterility 30(4): 444-447

1978

ISSN/ISBN: 0015-0282
PMID: 710616
DOI: 10.1016/s0015-0282(16)43580-6
Document Number: 436409
Azoospermia was diagnosed in six factory workers who had been chronically exposed to 1,2-dibromo-3-chloropropane. Infertility was the presenting symptom in two patients and a decrease in libido or impotence characterized the others. Hormone studies revealed elevated plasma follicle-stimulating hormone levels and normal plasma luteinizing hormone and testosterone concentrations. Testicular biopsy showed selective atrophy of the germinal epithelium, intact Sertoli cells, and a normal appearance of a relatively increased number of Leydig cells.

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