Effects of spermidine synthase inhibition on cytoskeletal organization in cultured chick embryo fibroblasts
Caruso, A.; Pellati, A.; Bosi, G.; Arena, N.; Stabellini, G.
European Journal of Histochemistry Ejh 38(3): 245-252
1994
ISSN/ISBN: 1121-760X PMID: 7530518 Document Number: 436309
The administration of bis-cyclohexylammonium sulphate (BCHS), an inhibitor of spermidine synthase, to cultured chick embryo fibroblasts provoked alterations in cell morphology, a marked disorganization of microfilaments and changes in microtubule network structure. In addition, the rate of microtubule reappearance, after disrupting them with colchicine, was impaired by BCHS. These responses to BCHS were prevented by spermidine addition, which thus suggests an involvement of spermidine in microtubule and microfilament organization.