Ichaemic heart disease of young women and their ovarian function
Soukupová, K.; Kobilková, J.
Sbornik Lekarsky 79(3): 65-70
1977
ISSN/ISBN: 0036-5327 PMID: 850770 Document Number: 433580
The ovarian function of 14 women, aged 23-40, with ischemic heart disease was examined. 4 of the patients had myocardial infarction (3 of which were transmural), 5 had unstable angina, and 5 had angina pectoris. All of the patients had a normal menstrual cycle and none used hormonal oral contraceptives. Cytohormonal examination was undertaken: assessment of the karyopyknotic and estrogenic index after 3-day intervals through the course of the cycle, the values of which were compared with ormal values. These data were combined with an analysis of risk factors in the patients' medical histories. 2 of the patients were found to be smokers, 4 were obese, 6 suffered from hypertension, and 6 from hypercholesterolemia. 1 showed a reduced tolerance to carbohydrates. 3 patients showed no risk factors. Hypoestrinism was recorded 9 times. In 3 of these cases the estrogenic indices were within physiological limits and 2 of them could not be evaluated. In all 3 patients in which no risk factor could be found hypoestrinism was found. It is strongly suspected that this ovarian hypofunction could play a role in the development of these heart diseases.