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Uncoupling effect of dicarbonic analogs of stearic and palmitic acids in heart mitochondria

Bondarenko, D.I.; Dedukhova, V.I.; Mokhova, E.N.

Biokhimiia 59(6): 911-915

1994

ISSN/ISBN: 0320-9725
PMID: 8075255
Document Number: 432936
The uncoupling effect of 2-hexadecylmalonic acid (HDMA) and 2-tetradecylmalonic acid (TDMA), the dicarboxylic derivatives of stearic and palmitic acids, have been studied in heart mitochondria. The effects of these compounds and related fatty acids on the induced by ascorbate oxidation with PMS (or TMPD) in the presence of oligomycin, phosphate and rotenone have been compared. It was found that both HDMA and TDMA uncoupled mitochondria with a similar efficiency as did the corresponding fatty acids, while the uncoupling effect of low concentrations of HDMA and TDMA were almost completely suppressed by carboxyatractylate.

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