The antistressor action of dibunol in surgical stress in lung cancer patients
Baraboĭ, V.A.; Bororov, L.V.; Gunina, L.M.; Maevskaia, L.P.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(5): 43-45
1994
ISSN/ISBN: 0869-2092 PMID: 7696906 Document Number: 431353
Dibunol (butylhydroxytoluene) in 1-g capsules was given to lung cancer patients, 4 g for two days and 4 g for one day before surgery. The level of stress was evaluated by the blood levels of cortisole, by the daily urinary concentrations of 17-keto- and 17-ketogenic steroids, and by the blood levels medium-weight molecular peptides and toxic indices 1, 3, 5-7 days of postsurgery. The antistress action of the agent appeared as twofold decreased blood cortisol and urinary 17-KS and 17-KGS 1 day after surgery, returning to the baseline on day 3 (while there was no normalization even on day 7 if dibunol was not given), and as significantly declined intoxication indices.