Pharmacokinetics and metabolism of synthetic androgen and anabolic hormone
Shimazaki, J.
Nihon Rinsho. Japanese Journal of Clinical Medicine 52(3): 624-634
1994
ISSN/ISBN: 0047-1852 PMID: 8164360 Document Number: 429725
Esters of 17 beta position of testosterone and nandrolone gradually liberate their free forms into circulation, which are metabolized through usual androgen pathway. 17 beta-hydroxy-17 alpha-methyl compounds, used per os as androgenic and anabolic drugs, show complicated metabolism, including saturation of A ring, degradation of substituted radicals at A ring, hydroxylation at 6 and/or 16, and epimerization at 17. These metabolites are excreted as free or conjugated forms with glucuronidate and sulfate.