Increase in the concentrations of brain serotonin and 5-hydroxyindoleacetic acid during growth of a transplanted murine lymphoma
Banik, S.; Ray, M.R.; Choudhury, S.; Lahiri, T.
Neoplasma 41(1): 9-11
1994
ISSN/ISBN: 0028-2685 PMID: 7515483 Document Number: 429436
The concentrations of serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were studied in discrete brain areas of mice bearing transplantable Dalton's lymphoma (DL). Marked rise in 5-HT level (p < 0.05) was observed in serotonin secreting cell rich area--raphe region--as well as in hypothalamus and caudate putamen. High 5-HT level in these discrete areas was maintained throughout the period of tumor growth. Appreciable increase in 5-HT concentration was also observed in midbrain at the late stage (day 15 post-transplantation) of tumor growth. Unlike 5-HT, there was little change in 5-HIAA levels at the early stage (day 7) of tumor growth, and this was followed by a fall in 5-HIAA level around day 10 post-transplantation. However, the concentration of this 5-HT metabolite increased considerably at the late phase of tumor proliferation. The results suggest a close relationship between serotonin level in discrete brain regions and growth of an experimental tumor in mice.