Reactivation of phototoxicity test for psoralens plus ultraviolet A by low-dose methotrexate
Okamoto, H.; Fukuda, A.; Mizuno, K.; Matsuyoshi, N.; Fujii, K.; Imamura, S.
Photodermatology Photoimmunology and Photomedicine 10(3): 134-136
1994
ISSN/ISBN: 0905-4383 PMID: 7947193 Document Number: 428806
Reactivation of a solar burn has been reported after administration of methotrexate for cancer and psoriasis patients. We report a case of psoriasis with a similar but delayed elicitation of phototoxic reaction by administration of low-dose methotrexate one month after psoralen and long-wave ultraviolet light (PUVA) treatment. The reactivation was seen in an already receding phototoxicity test area but not in a less phototoxic, noninterval PUVA treated area, suggesting that the reactivation by methotrexate is related with the severity of light-induced skin inflammation.