Felty's syndrome: response to low dose oral methotrexate
Isasi, C.; López-Martín, J.A.; Angeles Trujillo, M.; Andreu, J.L.; Palacio, S.; Mulero, J.
Journal of Rheumatology 16(7): 983-985
1989
ISSN/ISBN: 0315-162X PMID: 2504919 Document Number: 329905
We describe a case of Felty's syndrome with persistent severe neutropenia below 200 granulocytes/mm3, splenomegaly and repeated infections. The patient did not respond to treatment with intramuscular gold salts and lithium carbonate. After 2 months of oral methotrexate administration, 7.5 mg weekly, clinical improvement was notable: she remained afebrile, neutropenia disappeared and splenomegaly regressed. This clinical and laboratory improvement persisted 5 months later. Moreover, accidental discontinuance of the drug and later readministration supported the evidence that the improvement was due to methotrexate.