The interrelationships of hypothalamic structures and the endocrine portion of the pancreas in diabetic C57BL/Ksj mice
Kolesnyk, I.M.; Abramov, A.V.
Fiziolohichnyi Zhurnal 40(5-6): 96-105
1994
ISSN/ISBN: 2522-9028 PMID: 8521998 Document Number: 428556
Interrelation between the hypothalamic nuclei and pancreatic endocrine fraction has been studied in mice of C57BL/KsJ line which were hetero- and homozygotic by diabetic gene db. The immunocytochemical method was used to determine content of insulin, glucagon and somatostatine in the Langerhans islet cells and morphohistochemical methods were used to estimate the state of hypothalamic structures. It has been shown that regulation of the pancreatic endocrine function and metabolic processes in which it participates by the hypothalamus may be provided at least by two mechanisms: neurohormonal one, connected with hormone secretion from paraventricular and supraoptic nuclei, and neuroconductory mechanism, connected with the ventromedial nucleus and lateral hypothalamic region.