The development of the thymus gland in rat embryogenesis with progesterone administration
Churilova, N.I.
Morfologiia 107(7-12): 82-88
1994
ISSN/ISBN: 1026-3543 PMID: 8680577 Document Number: 428042
Thymus structure was studied in 16 and 20-days-old embryos after everyday administration of 0,3 microgram (treatment doze) and 3,0 micrograms/100 g body weight of progesterone. It was established by morphologic methods that on 16th day blast forms amount in experimental animals is significantly lower than that in control animals. Amount of the hormone, 10 times exceeding the previous ones was administered in the same terms and caused reduction of the mitotic activity. The data on the cell by that time were absent. Progesterone administration during placenta forming does not change neither does thymus location nor its structure in 20-days-old foetuses. Treatment doze causes increase of the share of the section area occupied with the cortical matter. 10-times exceeding doze results in more significant decrease of the lymphoid cells number than those caused by treatment doze. Progesterone dissolvent (apricot oil) does not cause significant changes in thymus structure indexes studied. Thus, changes in the thymus structure observed result from progesterone effect on the thymus rudiment during placenta forming.