Evaluation of the toxic effects of cadmium on the body in light of research on the behavior of lipid compounds in aortic walls of animals
Grabowska-Maślanka, H.; Janik, A.
Folia Medica Cracoviensia 35(1-4): 39-44
1994
ISSN/ISBN: 0015-5616 PMID: 8586327 Document Number: 427458
The goal of this project was to observe certain paths of lipid metabolism in the aorta under the influence of chronic cadmium poisoning. A statistically very significant concentration of cadmium was found in the aortic walls of poisoned rats. However, the concentration of cadmium was not changed in the blood serum, where only a slight tendency towards increase was observed. Among the lipid compounds traced in the blood serum, a considerable increase in triglycerides was observed. The increase in the concentration of total cholesterol in the aortic wall was slight but statistically significant. The concentration of other analyzed lipids--i.e. free fatty acids, triglycerides and phospholipids--did not change. The above observations suggest the hypothesis of the possible development of atherosclerotic changes resulting from chronic cadmium poisoning.