Comprehensive evaluation of inheritance and environmental factors in the etiology of primary liver cancer
Cheng, B.; Wang, X.L.; Xu, H.W.
Zhonghua Yu Fang Yi Xue Za Zhi 28(3): 140-143
1994
ISSN/ISBN: 0253-9624 PMID: 7842867 Document Number: 427250
A1:1 matched case-control study was carried out in 152 cases with primary liver cancer (PLC) and 152 controls to identify the risk factors associated with it and its cumulative mortality in their second- and third-degree relatives. Results showed cumulative mortality of PLC in the relatives of the cases (0.46%) was significantly higher than that of controls (0.07%). Cumulative mortality of PLC in consanguineous relatives of the cases (0.55%) was significantly higher than that in non-consanguineous ones (0.08%). Cumulative mortality of PLC decreased regularly with family relation (consanguinity) drifting apart. Genetic factors still played an important role independently in the etiology of PLC with multiple regression and stratification analyses studying genetic and environmental factors as a whole. This laid a theoretical basis to study further the association between genetic factors and PLC incidence.