Glycogen synthase gene-glycogen synthase gene in Japanese patients with NIDDM
Kuroyama, H.; Sanke, T.; Nanjo, K.
Nihon Rinsho. Japanese Journal of Clinical Medicine 52(10): 2726-2730
1994
ISSN/ISBN: 0047-1852 PMID: 7983805 Document Number: 426915
As glycogen synthase is a key enzyme of the non-oxidative pathway of glucose metabolism in the skeletal muscle, and reduced activity of this enzyme is related to insulin resistance, it seems likely that this enzyme is a candidate gene for contributing to the pathogenesis of NIDDM. In this paper, we review recent findings of polymorphism of the human glycogen synthase gene, XbaI restriction enzyme length polymorphism and simple tandem repeat DNA polymorphism, and discuss the possible association between the glycogen synthase gene and NIDDM.