Genetic control of cellular differentiation and proliferation during gametogenesis in mammals
Wolgemuth, D.J.; Rhee, K.; Ravnik, S.E.
Contraception Fertilite Sexualite 22(10): 623-626
1994
ISSN/ISBN: 1165-1083 PMID: 7804381 Document Number: 426786
Understanding the genetic program that controls the regulation of cells progressing through the mitotic and meiotic cell cycles, whether in response to growth factors, other extracellular signals, or intrinsic programs, is critical to problems in infertility and in gonadal neoplasias. In this study, we present a consideration of important stages of cell cycle control in mammalian germ cells and data illustrating the experimental approaches that can be used to determine the pattern of such genes which may be involved in these events.