Intestinal cell differentiation: cellular mechanisms and the search for the perfect model focus on "involvement of p21 (WAF1/Cip1) and p27 (Kip1) in intestinal epithelial cell differentiation"
Evers, B.M.
American Journal of Physiology 276(6): C1243-C1244
1999
ISSN/ISBN: 0002-9513 PMID: 10362585 Document Number: 503252
In this issue, Tian and Quaroni report a novel approach to generating a human fetal intestinal cell line, tsFHI, immortalized with a temperature-sensitive SV40 T antigen. The cell line recapitulates, in several respects, the well-coordinated in vivo process of active proliferation with subsequent growth arrest and a shift to a differentiated phenotype. tsFHI should prove quite useful in studies to delineate the pathways that trigger intestinal cells to differentiate.