Scleroderma of the shoulders after treatment with combined bleomycin and radiotherapy
Marck, Y.; Meunier, L.; Barnéon, G.; Meynadier, J.
Annales de Dermatologie et de Venereologie 121(10): 712-714
1994
ISSN/ISBN: 0151-9638 PMID: 7540814 Document Number: 425598
There are many causes of scleroderma. We observed a case of scleroderma involving the shoulder and neck area after combined bleomycin and radiotherapy. After six cycles of a CHOP-bleo protocol followed by radiotherapy for lymph node lymphoma, a female patient presented scleroderma involving the shoulders and neck area. Total bleomycin dose was 252 mg. Among the imputable factors, particularly extrinsic factors, in a series of 33 cases of different chemotherapy protocols published by Peters et al. in 1988, we retained the bleomycin radiotherapy administration sequence as the cause of this complication. Given after bleomycin, radiotherapy could increase the risk of scleroderma.