Hyperinsulinemia as a factor modifying sensitivity of endometrial carcinoma to hormonal influences
Vishnevsky, A.S.; Bobrov JuF; Tsyrlina, E.V.; Dilman, V.M.
European Journal of Gynaecological Oncology 14(2): 127-130
1993
ISSN/ISBN: 0392-2936 PMID: 8500494 Document Number: 421738
In 22 patients with endometrial carcinoma, Stage I-III (mean age 57.8 years) with obesity, initial and reactive hyperinsulinemia (during glucose load) was revealed. Significant correlations between values of "peak" and field-square of the insulin secretion curve and cytoplasmatic receptors to eastradiol and progesterone in the tumour were found. In a group of the patients with high values of reactive hyperinsulinemia significantly larger amounts of steriod hormone receptors in the tumor were determined as compared to the group of the patients who had low insulinemia values. On considering these data a possible conclusion was reached as to the modifying influence of hyperinsulinemia on sensitivity of endometrial carcinoma to hormone receptor synthesis in the tumor by insulin.