Monoclonal antibodies against D-antigen of the rhesus system
Olovnikova, N.I.; Deriugina, E.I.
Gematologiia i Transfuziologiia 38(7): 3-8
1993
ISSN/ISBN: 0234-5730 PMID: 8307287 Document Number: 421123
The authors review current data on the production and characterization of anti-D monoclonal antibodies. The main methods for establishment of anti-D antibody secreting cell lines are considered: EBV-transformation of B lymphocytes from immune donor and hybridization with malignant human or murine cell lines. Serologic and immunological properties of anti-D monoclonal reagents for blood group Rh-typing as well as feasibility of using anti-D monoclonal antibodies as a modality against hemolytic disease of the newborn are discussed.
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