The effect of low and high molecular weight dextrans on selected lipid parameters in serum. Part 3
Rühlmann, C.; Koksch, M.; Hohdorf, K.; Kuklinski, B.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 48(8): 381-385
1993
ISSN/ISBN: 0044-2542 PMID: 7691019 Document Number: 420972
After a ten-day treatment of 21 patients with low molecular weight dextran (MW = 40,000), a decrease in the plasma concentrations of total cholesterol of 25%, LDL-cholesterol of 32% and apoprotein B of 22% was observed. The HDL fraction only showed a reduction of 10%. These dextran effects were dose-dependent. During the post-treatment period of 20 days a continuous increase in the lipid parameters to the preinfusion values was demonstrated. Dextran caused stronger lipid changes in HLP patients than in normolipaemics.