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Chemistry of oxidative DNA strand scission

Sugiyama, H.; Fujimoto, K.; Hatano, K.; Ohmori, K.; Saito, I.

Nucleic Acids Symposium Series 29: 125-126

1993

ISSN/ISBN: 0261-3166
PMID: 8247734
Document Number: 420014
In order to investigate the reactivity of uracilyl-5-yl radical in fixed DNA structure, photoreaction of 5-halouracil-containing oligonucleotides was investigated. It was found that photoirradiation of BrU-containing duplex DNA provided C1' oxidation product selectively at adenine residue of ABrU sequence. In contrast, photoirradiation of IU-containing DNA gave C1' and C2' oxidation products with almost no sequence preference. Sequence specific electron transfer in duplex DNA is proposed in the photoreaction of ABrU.

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