Sequence-selective RNA scission by oligoamine--DNA conjugates (1)
Kuzuya, A.; Azuma, Y.; Inokawa, T.; Yoshinari, K.; Komiyama, M.
Nucleic Acids Symposium Series 37: 209-210
1997
ISSN/ISBN: 0261-3166 PMID: 9586073 Document Number: 480886
Ethylenediamine and diethylenetriamine, which are active for RNA hydrolysis, are attached to the 5'-ends of synthetic oligonucleotides by urethane linkages. The resultant artificial ribonucleases selectively hydrolyze the substrate RNA at the target phosphodiester linkage. Acid/base cooperation in the oligoamines for the catalysis is confirmed in terms of kinetic evidences.
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