Immunohistochemical localization of paraquat in skin and eye of rat
Nagao, M.; Zhang, W.D.; Itakura, Y.; Kobayashi, M.; Yamada, Y.; Yagi, K.; Oono, T.; Takatori, T.
Nihon Hoigaku Zasshi 47(3): 202-206
1993
ISSN/ISBN: 0047-1887 PMID: 8345682 Document Number: 419498
Immunohistochemical techniques were used to observe the localization of paraquat in the skin and eyes of rats. Paraquat poisoned rats were killed 3 h, 12 h, 24 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. In skin, paraquat was localized in the ducts of sweat glands and sebaceous glands between 3 and 10 days after paraquat injection. In eyes, weak positive findings were observed in nerve fibers of retina between 3 and 10 days after the injection. In cornea, paraquat was localized in epithelial cells at the first 3 h and between 3 and 10 days after paraquat administration. Since skin occupies a vast area of the body in animals, as an organ, it seems to be an important storage pool for the redistribution of paraquat.