Migraine: possible role of platelet insensitivity to prostaglandin E1 (PGE1)
Cerneca, F.; de Luyk, S.; Radillo, O.; Simeone, R.; Mangiarotti, M.
Functional Neurology 8(6): 403-408
1993
ISSN/ISBN: 0393-5264 PMID: 8150318 Document Number: 419205
Platelet aggregation inhibition, induced by prostaglandin E1 (PGE1), was evaluated in 38 patients affected by migraine. Our data indicate a complete insensitivity to PGE1 in these subjects. The insensitivity to PGE1 leads to decreased cyclic-AMP (cAMP) levels, determining an imbalance in the inhibitory mechanism. From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.