Experimental autoimmune uveitis and retinitis induced by S-antigen immunization
Misiuk-Hojło, M.; Ruiz-Moreno, J.; Thillaye, B.; de Kozak, Y.
Klinika Oczna 95(3-4): 101-104
1993
ISSN/ISBN: 0023-2157 PMID: 8377430 Document Number: 419183
Experimental autoimmune uveoretinitis (EAU) was induced in Lewis rats by a single injection in foot pads of S-antigen in complete Freund's adjuvant. Clinically, during the 2 nd week after immunization, EAU starts by acute anterior, lately--posterior uveitis. Peptide S2, located in the N-terminal region of S-antigen, has a regulatory effect on EAU, while peptide M is a pathogenic site inducing EAU. Antibodies directed at peptide S2 were observed in rats not developing EAU while high levels of antibodies directed at S-antigen and peptide M were present in all rats.