Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects
Legnani, C.; Frascaro, M.; Guazzaloca, G.; Ludovici, S.; Cesarano, G.; Coccheri, S.
Arzneimittel-Forschung 43(2): 119-122
1993
ISSN/ISBN: 0004-4172 PMID: 8457236 Document Number: 419178
The acute and chronic effects of a preparation of dried garlic powder (Sapac) in a total daily dose of 900 mg on fibrinolysis and platelet aggregation have been evaluated in a randomized, double-blind, placebo controlled cross-over study of 12 healthy subjects. Total euglobulin fibrinolytic activity and t-PA (tissue plasminogen activator) activity were significantly higher 4 and 6 h after garlic and placebo ingestion, and no differences were recorded between treatments. After 14 days of treatment, t-PA activity was significantly higher after garlic, with inter-treatment significance. No significant changes in PAI (Plasminogen Activator Inhibitor) activity and fibrinogen levels were recorded. Platelet aggregation induced by adenosine diphosphate and collagen, and especially beta-thromboglobulin (beta-TG) release after collagen stimulation were significantly inhibited 2 and 4 h after garlic ingestion; platelet aggregation values were also significantly lower after 7 and 14 days of garlic treatment. No significant changes were found in adenosine triphosphate release and serum TXB-2 levels after acute garlic administration.