Effect of megestrol acetate compound (injectable contraceptive) on human blood coagulation, anticoagulation activity, fibrinolysis and platelet aggregation
Cheng, X.F.; Shao, H.Z.; Chen, Z.P.
Sheng Zhi Yu Bi Yun 8(1): 22-26
1988
ISSN/ISBN: 0253-357X PMID: 12315407 Document Number: 357020
The authors studied the effect of a new injectable contraceptive, a megestrol acetate compound, on blood coagulation, anticoagulation activity, fibrinolysis, platelet count, and its aggregation. The results indicate that after the administration of this contraceptive for over 1 year, VII:C and VIIIR:Ag were significantly increased and PT was shortened. Fibrinogen antigen decreases were seen within 6 months of administration, and then these returned to normal. Antithrombin III activity and antigen levels did not change during the time this contraceptive was in use. Plasminogen and fibrinolytic activity were significantly increased after the administration of the contraceptive for more than 3 years. Platelet aggregation induced by ADP increased after the contraceptive was in use for more than 1 year. (author's modified)