Effect of Bordetella pertussis vaccine on bleeding time, whole blood coagulation time and platelet aggregation in animals
Ainapure, S.S.; Valame, S.P.; Dhar, H.L.
Japanese Journal of Experimental Medicine 55(4): 133-135
1985
ISSN/ISBN: 0021-5031 PMID: 3003424 Document Number: 250052
Bordetella pertussis vaccine, a hypoglycemic agent, significantly prolonged the bleeding time and whole blood coagulation time in rabbits and dogs when administered intraperitoneally. The vaccine also affects platelet aggregation in rats 4 days after its intraperitoneal administration. The effect on platelet aggregation is thought to be due to its beta-adrenergic receptor blocking action which may also contribute to the hypoglycemia.
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