Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy
Zastawny, T.H.; Olejniczak, W.; Oliński, R.
Acta Biochimica Polonica 40(4): 555-558
1993
ISSN/ISBN: 0001-527X PMID: 8140831 Document Number: 418595
Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cis-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.
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