The present status of nitrates in the treatment of ischemic heart disease

Stejfa, M.; Vítovec, J.

Vnitrni Lekarstvi 39(2): 172-177

1993


ISSN/ISBN: 0042-773X
PMID: 8506665
Document Number: 418236
The authors describe the development of nitrates from substances of the first generation (nitroglycerin and isosorbit dinitrate) to the second generation (isosorbit-5-mononitrate). They explain the mechanism of their action, haemodynamic effects and the problem of nitrate tolerance. Indications of their rational use are given.

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