Hypocalciuria in pre-eclampsia
Rodríguez, J.G.; Avendaño, R.; Inzunza, B.
Revista Chilena de Obstetricia y Ginecologia 58(6): 470-474
1993
ISSN/ISBN: 0048-766X PMID: 7991873 Document Number: 417248
Recent studies have associated preeclampsia with hypocalciuria, nevertheless others do not show association. We proposed to determinate if this association exists, so we studied 25 term pregnancies patients (13 normotensives, 7 transient hypertension and 5 preeclamptic). We did not find significative differences in the hematocrit, serum calcium, serum creatinine, platelets count and the 24 hour diuresis between these groups. The serum uric acid was significative lower in the normotensive group (3.5 +/- 0.8 mg/dl) than in the preeclamptic group (4.9 +/- 0.89 mg/dl) (mean +/- SD) (p < 0.05). The 24 hour calciuria was lower in the preeclamptic group (121 +/- 78 mg/24 hours) than in the normotensive (256 +/- 71 mg/24 hours) and transient hypertension group (229 +/- 93 mg/24 hours) (p < 0.05). We measured the creatinine clearance and the fractional excretion of calcium in the transient hypertension and the preeclamptic groups, there was significative difference only in the fractional excretion of calcium (2.5 +/- 0.8% and 1.1 +/- 0.8% respectively) (p < 0.05). All the patients had a good clinical evolution, so the arterial pressure returned to normal values in a mean period within 7 days in both groups. There were 3 newborn who were small for gestational age (1 in the transient hypertension and 2 in the preeclamptic group). The difference we found in the 24 hour calciuria and the fractional excretion of calcium agree with the finds of other authors, further prospective studies are needed to understand the physiology and pathophysiology of calcium metabolism in normal, transient hypertension and preeclamptic pregnancy.