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Study on initiation of human lung carcinogenesis

Li, Z.; Qi, Z.; Wei, H.; Luo, X.; Feng, Y.

Journal of Environmental Pathology Toxicology and Oncology Official Organ of the International Society for Environmental Toxicology and Cancer 12(2): 81-88

1993

ISSN/ISBN: 0731-8898
PMID: 8189362
Document Number: 417187
Cigarette smoking condensate and diethylnitrosamine can initiate human lung carcinogenesis as they are able to induce precancerous lesions of bronchioles and the transforming ability of human fetal lung (HFL) DNA. The induction of precancerous lesions in HFL and the acquirement of the transforming ability of HFL DNA by short-term exposure to carcinogens can be combined to yield an ideal model for the initiation of human lung carcinogenesis.

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