Degradation of succinylcholine chloride
Németh, G.; Török, I.; Paál, T.
Acta Pharmaceutica Hungarica 63(3): 151-156
1993
ISSN/ISBN: 0001-6659 PMID: 8362654 Document Number: 414200
Quantitative thin-layer chormatographic method has been developed for the investigation of the degradation of injection formulations containing succinylcholinium chloride. The method is based on the denistometric determination of the main degradation product, choline at 430 nm after visualization with iodine vapour. The stability of the injection was investigated under various storage conditions and it has been stated that considerable decomposition takes place during as short a period as one week.
Document emailed within 1 workday
Related Documents
Chen, Y.; Chen, Q. 1998: Effect of different doses of succinylcholine chloride on its action duration during rapid anesthesia induction Hunan Yi Ke da Xue Xue Bao 23(5): 510; 512Yamaguchi, T. 1973: Relationship between the blood circulation time and the latent time of muscular fasciculation following succinylcholine chloride injection Masui. Japanese Journal of Anesthesiology 22(11): 1285-1292
Kuze, S.; Murakami, S. 1973: Mechanism of neuromuscular transmission. The effect of succinylcholine chloride on phase II block, with special reference to the effect of a small amount of d-tubocurarine on preparalytic facilitation Masui. Japanese Journal of Anesthesiology 22(3): 208-217
Kendig, J.J.; Bunker, J.P.; Endow, S. 1972: Succinylcholine-induced hyperkalemia: effects of succinylcholine on resting potentials and electrolyte distributions in normal and denervated muscle Anesthesiology 36(2): 132-137
Döge, G.; Pohloudek-Fabini, R.; Kottke, D. 1982: Analysis and stability of suxamethonium chloride. 1. Detection and quantitative determination of the intact active agent with its degradation products Die Pharmazie 37(10): 708-711
Fukuda, K.; Matsushita, H.; Sakabe, H.; Takemoto, K. 1981: Carcinogenicity of benzyl chloride, benzal chloride, benzotrichloride and benzoyl chloride in mice by skin application Gan 72(5): 655-664
Li, W.-M.; Bao, Y.-Y.; Zhou, Q.-X. 2012: Degradation pathways and main degradation products of tetracycline antibiotics: research progress Ying Yong Sheng Tai Xue Bao 23(8): 2300-2308
Bohley, P.; Miehe, C.; Miehe, M.; Ansorge, S.; Kirschke, H.; Langner, J.; Wiederanders, B. 1972: Intracellular protein degradation. V. Preferred degradation of short life cytosol proteins by lysosomal endopeptidases from the rat liver Acta Biologica et Medica Germanica 28(2): 323-330
McKerrow, J.H.; Keene, W.E.; Jeong, K.H.; Werb, Z. 1983: Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host Laboratory Investigation; A Journal of Technical Methods and Pathology 49(2): 195-200
Kedar, I.; Sohar, E.; Ravid, M. 1982: Degradation of amyloid by a serum component and inhibition of degradation Journal of Laboratory and Clinical Medicine 99(5): 693-700
Krácmar, J.; Cechová, J.; Alvarez Sotolongo, M.; Krácmarová, J.; Haller, A. 1978: An analytical study of 2-ethylamino-1-/3-trifluormethylphenyl/-propane (chloride fenfluramine; chloride trifluethamine) Ceskoslovenska Farmacie 27(10): 445-451
Brammell, W.S. 1976: Loss of chloride in the official method for the determination of sodium chloride in cereal foods Journal - Association of Official Analytical Chemists 59(6): 1396-1400
Dracheva, L.V. 1990: Determining the levels of chloride ions in water solutions using a chloride-selective electrode Gigiena i Sanitariia 7: 71-72
Fleig, I.; Thiess, A.M. 1978: Chromosome investigations of persons exposed to dimethylcarbamoyl chloride and diethylcarbamoyl chloride Journal of Occupational Medicine.: Official Publication of the Industrial Medical Association 20(11): 745-746
Welty, T.E.; Cloyd, J.C.; Abdel-Monem, M.M. 1988: Delivery of paraldehyde in 5% dextrose and 0.9% sodium chloride injections through polyvinyl chloride I.v. sets and burettes American Journal of Hospital Pharmacy 45(1): 131-135
Schwiebert, E.M.; Flotte, T.; Cutting, G.R.; Guggino, W.B. 1994: Both CFTR and outwardly rectifying chloride channels contribute to cAMP-stimulated whole cell chloride currents American Journal of Physiology 266(5 Pt 1): C1464-C1477
Nishida, M.; Sato, K.; Kawada, J. 1990: Differential effects of methylmercuric chloride and mercuric chloride on oxidation and iodination reactions catalyzed by thyroid peroxidase Biochemistry International 22(2): 369-378
Gardavská, K.; Vitková, Z.; Cizmárik, J. 1994: Study of local anaesthetics: Part 124. Influence of the ointment bases on the liberation of pentacaine chloride and heptacaine chloride Acta Pharmaceutica Hungarica 64(5): 167-170
Lote, C.J. 1976: Chloride transport in isolated frog (Rana temporaria) skin: changes in short-circuit currently, potential, resistance, and chloride flux elicited by furosemide Pflugers Archiv: European Journal of Physiology 362(2): 181-184
Dennison, J.L.; Breder, C.V.; McNeal, T.; Snyder, R.C.; Roach, J.A.; Sphon, J.A. 1978: Headspace sampling and gas-solid chromatographic determination and confirmation of greater than or equal to 1 ppb vinyl chloride residues in polyvinyl chloride food packaging Journal - Association of Official Analytical Chemists 61(4): 813-819